ࡱ> 8567n s#ڿE`" PNG  IHDRKMiPLTEŽŽ{{{{sssskkkkckccccZcccZZZZR{RR{{RJ{{{JB{sssssB:ssk::skk:1skckkkkkc1)1!kcc11kcZ1)1!cccccZ)!))kZZ)!)cZZcZRZZZZZR!cRZcRRZRRģbKGDH cmPPJCmp0712HsIDATXGVmOGsruQ?8 EH` ’c;E8?ή}{Ub33>3{?[bg+5|[};2yw"3uWڥ>OxhnFٷI^a p6Dv`㶲+k`^#8wkl4ڲUy fr2 ~ 6v, 6%0@S 4'2\c ه c[`3.36bQ\!Q$ 0|g-ø,tyR>"NaĿҴXd ޘ'I?DzR%}#GNKy5Xwd7* m{aC hәBhSh&" t$nB%XՔNQDL!ر|o"X!3®:[qp 1䴈Ή9 N%Ģ8o9-nrq?_z?5~njlS:X9WG:e hP!$GcR҇F|X]VT{ANXDQ>'a#K!X (jāp.G+V|LTGq!a`?:<[NGMoo"~,Agߛ'7j1<=EBjjlj :B6l |7uӰ`l:,bMA cKFډ0ijYf-qX9*VjWߙˆ+k/|nDH WMn_Ywa+X_ZAw ]p!6pfV/*Y5iNMWcS2<ua˻)E,@,*Ta|WQw}vX l3:b_Y^ք _hp@jXR"jL (Xl8$ p^uC7`X]T5%Cv{/kMXXa}1f1,ߤs`)ӀJ"y~J(_dbL2mJ^b5x%ϐFEV@N:'ozίG | GARE|5O<(tM׸`k@zܤIu6  X=G:_ʊB! _4Ȏ}E$&@PbC}aͳv t>GV@WoA/jtY0O꾃7{fYhN8zn̡<1iv&fdfk *iJ)86.{1 [HmɺQiUx>?&DJRAHai.<'h֎h"xM~2I' 6IENDB`n$>I$PNG  IHDR!4CPLTE3f3333f333ff3fffff3f3f̙3f3333f3333333333f3333333f3f33ff3f3f3f3333f3333333f3̙333333f333ff3ffffff3f33f3ff3f3f3ffff3fffffffffff3fffffff3fff̙ffff3fffff3f̙3333f33̙3ff3ffff̙f3f̙3f̙̙3f̙3f3333f333ff3fffff̙̙3̙f̙̙̙3f̙3f3f3333f333ff3fffff3f3f̙3f (((555CCCPPP]]]kkkxxx?7b@`E?7@7Qzp>(B!{({,BO;]8bKGDH cmPPJCmp0712HswIDAT(S Dacccswj&h>sXrhb/ ,Tl"-3ؖ#_Y6]ݟ(B{({,BǛGbKGDH cmPPJCmp0712Hs]IDAT(S1 {5QhǶIϢ՚}f: @O,9OoSPѿb~{ pK,uIENDB`@=.efc zR#:>xm]ys2c5(5qS L Rq)q"ȱ:E QҖRB%J$D"">P"*!Q*?̝]].z登s{uuԉw]DT͝u/5v3TGP+޵}{-mX!; /]tis I~]w E9ҝ$ϡI˨5N|kWۙϾuM΅{-X}>~;ع|}{6vo9 Ǻ;f]Wny;Я}whaӦiu׮Ooxsqy7dc-9%}~_ ~%T=Gw܈~OuVޗ3>@{yGHqMy>e9] O?:7ybz\vorZB 8^d#w|5|Pt oS:Թ\o$c%k|סi{/CmrGx^͟PTކm2j﫲S<ԨʺԨz,&w͇1wq̵sX6$kem<免cePcu eygu Vv5F?IYRV窬K27$k.<﮲.'Y) * j~QVWY1I~Uʁ'Y(*j~uQVa庡'YQrPc(&UMXy1I͔u e*:$Vʺ|{uVnj~u;eAYyʺ+w5F?ɺ<]e݅dMYPVﭲʽCO(+WYa'YSPc)!UCXyx1IÔe*<:$QzxVj~8e=AYy~z+O5F?z^XB!nz XKK+:]7+sO>~?~~\/}W#tmI{eۮ|yvM.5%]~S_Rފz(}r8N/aIy啕7%Se {9Vۆ~c>&>a?1Y:&>ctL[J1:&/)o8L7}L/rL+f8&;\111GEKʛ>&.c.)ot;zƒ򦏉3v%M{=rcKا_c%M1%McbӒ򦏉MtLc4:&N[m5t 1Q_ﬦr?k_weuo~Jڮz[f϶G<^;ߗ[lJ۴}vW6E~bvuW5כ>b~-{n}-=cyjn]뾈_u_/r۹u{?}{OMNw!qw^E{]y=}cܮ}^vߧoS?1þ%WzvߧoS-?D_6fym{xmfߐ_>} |u#tW,rz3;ؑcn:uB[x￬6unF~Azԋftjzn@r,}MlN=K;eӷg95=_'9vߧoSOgsjzcsߧoSOgsN]L}嬏Sٜ >[9u{g.;|e<_ѩ_Y>}zɌN.N9SQl}6uS?SvߧoSOgs/GzY wL}>W\3b?~SlszNܜ䫨cg:Ϭs¶|zyMiqD>nDawZ[7p f7mS%))mq~Yڪ~Uь_ nK^}jԟ#|9suZ}cI![8 ܶQf>m12fɱxmγ-gͳ?醴|"m)T_f̯Ϙi;Of>mŢɭCf|}rܳr*{\?svM=g|ڊE/3[r"{`ܯ̜kKw?滋\N{FzSV~ǟե}5y~S׳'vG'GuŮ~POK}Xs^=~R^Ok*?v^QWfx A}+s93'Wwcgݖcxlc{7s@U3?SKԕr%q;uuڻu|^ka%mB{VUicޮxYy;چ{"K޵r#&nn(B.{({,/BDbKGDH cmPPJCmp0712HsIDAT8O; Dyydp!l-+:*rOc⋶Ivft:Z^:aJnpxp@wN< 9&pv3]'D3S|Kq. } 2~$﷚~IENDB`@=h)cHfKMr:^#:>6)xqe}vsa Bq$ u1\NpA<{KV\gK !5]΍R5EI,ڒs#6[YDPJUe*T#^u%ˊ\+"=:͎~|7o^V!BXV#VGlWgWwZBu.?phUmgzzsz-.}W^Y]w"|!buLEy-S}߆ӵ\ra:^w~~ї;5^~xw\_߽xu=_N.o/{޻5{Ot?܅ 4u]c^ f|>i|Չdž~[Ӎ'k_+?|?E#ߧYr{y~?1Tv&y^xXGnY߈,pt_m8r˜mE-vZ#EqȜE:J]tőlG۩ԵNJwȱ9;cu'u-]Eם8rל΢.꺇ޢwf}Ou/uG]~u?g躟Sײ?XtǑlNj}Ե]Ñl+Sײ?\tGYz>@]HydfzQylfhu=N]q!Z's6]OPדԵzGɢ+RSԵ.‘٬*>L]eh#EGcԵO]Ñl+Sײ?St}GYzeD,|bfl $u-Tt}G9'>E]S89OSgkٟ+>#٬?St=G]e,G]s89犮Sז EG0g]_/Rײ"|ifŢKeZ]_Ƒ٬\t}J]89WQԵ_/^Ƒ٬_.N]uײZo]YXk]0u]H]~Qu!z.Y_Xt]D]Pײ_Zt]Kl֗]Rk/+^l֯+.˩kٯ(.Gs6ˋ+JZ+s՜ʢ*꺚 EyÜ u-u-uE׵nf}muuEכ97S[ko(ނlo)nko.nBs6뛊Z[[s-E׭uZnY)n۩k}u;zS1Z;ccf}躃e =w٬*e/.kV?Hj6µm+Z%ZmmkZI ۶m-֒mڶͶpmʶlkɶfZV¶me[Kd[mm-\+ia۶%ZU۶ٶm[֒m-֪ml[ JZضlkɶlkնmk%-lVd[Kj6µm+Z%ZmmkZI ۶m-֒mڶͶpmʶlkɶVmfZV¶me[Kd[mm-\+ia۶%ZU۶ٶm[֒m-֪ml[ JZضlkɶlkնmk%-lVd[Kj6µm+Z%ZmmkZI ۶m-֒mڶͶpmʶlkɶVmfZV¶me[Kd[mm-\+ia۶%ZU۶ٶm[֒m-֪ml[ JZضlkɶlkնmk%-lVd[Kj6µm+Z%ZmmkZI ۶m-֒mڶͶpmʶlkɶVmfZV¶me[Kd[mm-\+ia۶%ZU۶ٶm[֒m-֪ml[ JZضlkɶlkնmk%-lVd[Kj6µm+Z%ZmmkZI ۶m-֒mڶͶpmʶlkɶVmfZV¶me[Kd[mm-\+ia۶%ZU۶ٶm[֒m-֪ml[ JZضlkɶlkնmk%-lVd[Kj6µm+Z%ZmmkZI ۶m-֒mڶͶpmʶlkɶVmfZV¶me[Kd[jm-&ia۶%ZU۶ٶm[֒m-֪ml[ JZضlkɶlkնmk%-lVd[Kj6µm+Zݧm ӶFmdVMe[C5d[mm \+i`ۦ!Q6ٶ4mS֐m vٛl[JضlkȶlkԶMk% lT5d[C5j&m*!mmkZI6m ֐mڶɶ5pmʶlkȶFmdVMe[C5d[mm \+i`ۦ!Q6ٶ4mS֐m ֨ml[JضlkȶlkԶMk% lT5d[C5j&m*!mmkZI6m ֐mڶɶ5pmʶlkȶFmdVMe[C5d[mm \+i`ۦ!Q6ٶ4mS֐m ֨ml[JضlkȶlkԶMk% lT5d[C5j&m*!mmkZI6m ֐mڶɶ5pmʶlkȶFmdVMe[C5d[mm \+i`ۦ!Q6ٶ4mS֐m ֨ml[JضlkȶlkԶMk% lT5d[C5j&m*!mmkZI6m ֐mڶɶ5pmʶlkȶFmdVMe[C5d[mm \+i`ۦ!Q6ٶ4mS֐m ֨ml[JضlkȶlkԶMk% lT5d[C5j&m*!mmkZI6m ֐mڶɶ5pmʶlkȶFmdVMe[C5d[mm \+i`ۦ!Q6ٶ4mS֐m ֨ml[JضlkȶlkԶMk% lT5d[C5j&m*!mmkZI6m ֐mڶɶ5pmʶlkȶFmdVMe[C5K;/gۗԭbۗKҶxm_R.]oÑ[l1nSײ)ގ#Gl1ﺎPQ*(>gyu;uXN96gyueGż뺋eGż뺗eGż뺟Sײ?XtǑl1Qײ?TtGżzO]p~yxau-#Ep9[̻GQZNJGq9[̻ǨqZ]l1>H]e<1gyu=I]'q$buEzES89[̻SGk?Zt}G>:gyQu-Ep9[̻Ե]Ǒgl1ﺞgk?Qt=#żu}}*>#Ӝ-]D]et)-]ק3Ե]l1ﺞRײ?_t}Gżz^ezG^żz>G]s89[̻Sז EG0g;mEZ/]_đ/bu}L]89[̻PWkٿVt}G6gy5zE89[̻SXZvqu`vк:pu>zbu k/*.DEsw]Q%Ե]9[̻KuԵ]Cesw]QԵW]9[̻+JZ+s՜-]Uu5u-9[̻7P׵Ե]ע9[̻MԵo.ބ7buB]~C0gyuuD]~suznż뺙ne=buJ]Gko+9[̻ۨvZv_tݎ?gyu-E11gyuuE]~wuzż,[v-~lȶiM)6aLʶlȶI:e& T6m6[lۄ]2a*&m".mK&SeDMdۤnmvɄylȶlԭSm.0Om6muʶM%橲m"&mRNٶ dcʶlɶ^gzs_֓m=֫[l[]c+z'zukmKz}e[Od[nm=vIlɶlխ}.1m=֓m϶%=澲'zWٶWd[O>cʶlɶ^gzs_֓m=֫[l[]c+z'zukmKz}e[Od[nm=vIlɶlխ}.1m=֓m϶%=澲'zWٶWd[O>cʶlɶ^gzs_֓m=֫[l[]c+z'zukmKz}e[Od[nm=vIlɶlխ}.1m=֓m϶%=澲'zWٶWd[O>cʶlɶ^gzs_֓m=֫[l[]c+z'zukmKz}e[Od[nm=vIlɶlխ}.1m=֓m϶%=澲'zWٶWd[O>cʶlɶ^gzs_֓m=֫[l[]c+z'zukmKz}e[Od[nm=vIlɶlխ}.1m=֓m϶%=澲'zWٶWd[O>cʶlɶ^gzs_֓m=֫[l[]c+z'zujmKz}eYO#ۺ}֩[l[]a*:#:ukmK:]e[Gud[nmvIlȶl].0wm֑m˶u%殲#:SvٶUud[Gu.atʶlȶNe:sW֑m֩[l[]a*:#:ukmK:]e[Gud[nmvIlȶlԭ].0wm֑m˶u%殲#:SvٶUud[Gu.atʶlȶNe:sW֑m֩[l[]a*:#:ukmK:]e[Gud[nmvIlȶlԭ].0wm֑m˶u%殲#:SvٶUud[Gu.atʶlȶNe:sW֑m֩[l[]a*:#:ukmK:]e[Gud[nmvIlȶlԭ].0wm֑m˶u%殲#:SvٶUud[Gu.atʶlȶNe:sW֑m֩[l[]a*:#:ukmK:]e[Gud[nmvIlȶlԭ].0wm֑m˶u%殲#:SvٶUud[Gu.atʶlȶNe:sW֑m֩[l[]a*:#:ukmK:]e[Gud[nmvIlȶlԭ].0wm֑m˶u%殲#:SvٶUud[Gu.atʶlȶNe:sW֑m֩Sl[]a*:;m;1_+xͯ._vױ䵫߮@_߬SR6ZieW{..Υ+^ߢ^]~+]~+]nrK/Qtwî/߽^/;_-wvN!cx-z?&_3 -}{ypP =.^Um.D6?ӷοx3=^<#{|Go_Tsۗ?_M6>z㙳;$UY2U[uʯ{>g1\q O|Y|nOlNO'Y|HtxNOu.9{VEד3]wy^ s7}gNws=gycuL~M+s=ə?Z}}Nv~jun<~yJZ}ͼ^7>kOrOޗ>wn^~>e?|9{O3__{_П䯩i?9{O>Is5><~>ֿ{؞iF|!:szy\on\wܸ\&U{+WX{uz|u]߃8 Gz·r>1zyAqْC} x.o)k&J4y̿/)ՉDZ\>U`FKG8)7_:_\H;s}g89>G8/88=9C߱snsZ_9_snsv>N|KYoA~E \].;ǬۿMsNַ{t.8ԵsgGM'k'>{={d}m|g|ޟӷoޟwo{_ի{ ~w$>Oi?ypryx3+Ys/|6޸:a}>{9\v׫_Swus?=߯{~q;WyN~s9vg w{j~Ag;3N{Jg;Չ/YyZ3?gpN{i>O>pܷz`uc{8:߿O^Z|l[o}>}B?_s=u|W#/_>{~:DU;>Xޕ@ϡ>mݿOolT*6s,cy]MZTPa}lBZ-gC@=D;W[-f$:'>xUyƿ/^1 K%A0R )$ǔ %9"J1E&B#934mX&VL5"RsfNDJءԉ)eN)Z-9gy޻pdewߺ"YȦAߥWgT WSUU*F꽸4 G-? oEV^x/[1Tuݚ7rƜPVGYi[~h2O䷑WoKg]uiju>_!'T3zٟއ\y: 9.&r+̱X.}>'22m}a}#㮒c0I UyXEtE#+k2YӤU_*b~mƺ #k2Zb#VguYߤUXub1c]MZuk#n V7e0I!cm"֍ĊFܤUߘn&-Ċu F67iշdĺX-c݊ۚ[3mĺXߚn&Xw+2֤Uߑk;bgڎ;NbMߓ=MZbKߗ}MZ>b Vwf٤UX;b+c=]MZk$VXb&v+gyIޝ&֣ĊcQ<֤U?#ĊF4iOd=zX*c='3SKX{1Iޛib4FiҪXk?blڏgYb=G?MZsyb@ؿ^ȋMZ EbDX/a@VR:@Qbž;QԵUf,LKVX#֤UaĚIط2LpZMŽ"֑Ċu$8#3lbCXǀ3I>&c!qĊ8poҪXDb~n:MZk.+3-c-$"b~qZ&zQZL%Ċk 8g6i:3X_I^\b~E:MZkV+d\ФUXBbu!85ifu biƺKK2֥ZEدXYݤUXX2c&zMƺXk3ZpnҪfXߐփI^6+;CKڨUm\!?+0IuXW+k3UYۤZKuĊ#뛴QwXub1c]Mڨ;ĺXߔnȦ&m&bHߜnMڨ;u b9c݂Mڨ;ĺX-c݊ۚQwXvb~kƺ#[QwX[ub-c݁mMڨ;mNߙc&m֝ĺX'cݍ{QwX^bu/FkFaGĊΌ#;QwX;b+c=]Mڨ;]zX(c=QwXk7bpڍQwXQb(FkFa=F'= iFa!֓ĊSI<դzX{}k/ڨ;}zX&c=gQwXk?blڏgQwX9bFoFa=O3 yIu"^"Vd0rIuuXĊadb%mV]d5aMڨ;È5X3'"kf설jHb~v:Mڨ;:XgN6k#VXǁs|6xbHX'3Iu5Xk8QwXub0c&mBb-"VgE,nFa-&b̌3QwXgk)b,c-gY6k%VWdsYѤZAĊk%84i. օĊEBp.jFa]DKK3%\ڤúXk8QwXX2c&m֕ZK_ւsu6jb'V7dlhF.1gžt䐮Ot}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t?|rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q!9#t}rH^Q9! 9!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MCҠXԶpHCi!MAҠXԶpFCitHEtHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*rHP'T%.RC*r=?:9dZΨ!$> H_Wi'g;wA#}u/Ϡoe˔VdN}i>}w4tC MWq+n|Io+MJẜ>L/hzWկb@ϋl"dA4/gd¿t{rv{lU)M}~10 <\Nt|?@iq~~\|w PnX~~m祴mo}Rylۯ6||eli߆mچC p g g}=s΁i]i`O 6<0o6<@zmx mS߆6Wr\Iٹ,MyqxN^^êu}?c~vo(<_?{LPe}Ls0AɃ.~5[χzG^G_@2-=kӿrӊxf*GkP? A8/x;=&ω?c~! $>>C.WȌzl yۙ1tߟd\=??dqS? 8/x;9|'~Fg/ccxs*ks ݯ`k׋?Y&~MGkyHDU>U8DϩOEZ&\f} :_|窮av]w'9ޞ=Ώ~p.ǹ>]Ga]^.+χ沏|2es{B>r57cP\i]++C]d>dϧ(-.3oۼ#Wvv&Bv7Tz]ש]5'gο#_@\?XrD#q1\IԽׇNǜ>(F>4ԩ}3Lw?>~g}">Ɵ>z̩N cC58Xo߇0zk1wGNzgfg[:EΎӰLU7ή> 'nK]K_g.y쨫I2dVVcji$,83߅y41i=@q/GN  sn64 W8 ۍW &_z_ۅ/ձʎ-9ίǼl5qZcka?\.3|'1 ӅHE כ^g\LLyz~x8]t_pM]qڴhA};S^AW?? _پ9àEv^n!್<6?csh ^;Ӱ?{Oria~?Od9&Wsܝ}{ : Mygd֌Lpޑ[oPzݚ4bs^[ʾ- ~9/ׇ#R4gy[yZއuyWcaZ_>ً9<םqv6s}@=MQq_}yNqf$:'>x\U}{ϐUI01R )$bcHr""c4s  RTL 2b12-ʠERl_9{{ OI>K~sw?{{?d6;wOUo7U7 UՇqIo1R]P@y>VbP5Ճ5[Uo u+̳Ӑw"~h2O䷑ǐr]YVZ^}Z,wnoFwd1gՁEB3SWՖS{mNyfn'~E/Z7,]{ũ,M&r16nܧW]fw2E=vUa>>#,S}fWo[uه+l37| rߕE2˂INyGP6:FX'ߐ:uDn1=ou"o::zlǁX==v=}"<#eus})e9DU9sAg~ )^O cNF \38sHx,q`>#cxﶼ갼ޓqe9YӤeժ%VXsXV}h:XG+ 2,hҪX u4bl:c3ֱZH/X YܤU/XX_I^kbRZIMZ$b-'VWdhҪg:X_NgUV}ZZEĊk587iի3:X?3cΙMZLbE؟&u6+k3p6ik2Zb#VguoҪe@_6saV!c]HMĊ挵 MZXϽ0w18}7W"]E܃^Fݮro'aduMڨ;uĺXߐ.Ȇ&mbm$V7eԤDK-liFam!Ċ֌u9F6i bʌuFlFa]Im*lkFam#Ċ5j\ӤúX+3ޤNFhFa -ĊڤúX+wd0rG6bIߕ]Mڨ;ub3c݃Mڨ;ĺX/c݋QwX~bu?FhFa=@3CyIu0!VX`&mczXߝ&mnb=I?SMڨ;4b'c=n6k+fyIu,#VXa&mzX1cQwX/%bF^nFaLWW3+yIu*F{H]Kڨ;.Y#uɊ5&mtb"֬Ț<;!iZ:XgN6k+3ҐC>?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆?! zEm 4䐆! zEm g4䐦OT䐪OTurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"TurH^Q!9"CѨuጊRM␿;p==?2쾰N@'{y,8!p/S3>Vdi=t[{h醦 W\ܿ4};M>M>Mth2[:ᐿo0E@VCr }o[|O6-;JGewjΛwb*? ej`s~;u3΁xӊx|xn P3;w<Ki^ǥnPwY:|tTwY:|f u ù p.=7~ΧYps@.YӺghV 밢xBZux\=~=ǏGfDz8#'KkWV!:o~x1=_/N4IO/US{Le61y_61zvak31&I_cM=~~}L+TlqᵕA8/x;wO2}W{cX't*Oknq^zmv&:ǞL'11\7Eߘtk33w{d =܃{c89E`25lq^zmvzq4zLsnu=9|Np؉S칋tpc2EUMsU0_Sǻgd`s y~{ǟShxO;??}c/}wV]Wo@޲i]+͎+C]dǕ>dϧ('\f߶yO8z07^bڃM=˟^/ujcdqy\oo n1SսǮ޶}gu_E?RB?c>ǜay 3ףz\S/ά̐K\rO]MHV 0G&N'nEa;x8=1]sM\ꬌ{.𙅜 Mbpe6z_%/m]__օ/->ZZ^l<8\.kdO]z0w\Bpxh̥ĔӏSfi'cgvaizEN{_ys{bzO#># ZWqpǷ/8njIL]o<%|F\^;;ds\I/%[7F~+/5U>-~!/̙yO̮n>ZL6#~槳_HWuvs*,>E[!\ga쭁+JŸ?(h}|Y}i^^gGЎ V} .s9 r$7׃!o4D6%=}L0oW.|g?p<>~98v噓*[MfTⷹoyɺ}vdd4ns߼Ϳ}sh ^3={ody92o Is}b#η5i>6PܶwF&Lǝmܶ'8 ||𞑯پ[>z.iu| rٹ0-|kFE`h ׍\<;zE'@=HҷbPs_Df$:'>x Uǻ3Id!fMpH1Mbp.|ZI(L$ź5WXsWhU%  1lX@Z)b}af& z3O~)Um)b;T|`^QEqrZQeۋxCa~C]X,:]7Ct~}e+=[Ykgz79|X.:O7}2^?s_S$0&]?֏c{M'6mdM#PM3&Om2SwN'Wm{`mz=b==^<4ȹy4}8㛡[ߩޢ9NNҌ.:TF{$"hN;miT9-T_g~Q#*M"nUIֻ18Bd-6YLV'Y0†p182m?^Ql+0ȣ`?V#`xG3lG"g `?XنE Ëy>l6| /}?6m?^Ql+0ȣ`?V#`xG3lG"g `?XنE Ëy>l6| /}?6m?^Ql+0ȣ`?V#`xG3lG"g `?XنE Ëy>l6| /}?6m?^Ql+0ȣ`?V#`xG3lG"g `?XنE Ëy>l6| /}?6m?^Ql+0ȣ`?V#`xG3lG"g `?XنE Ëy>l6| /BN5d2YdB g `?XنE Ëy>l6| /}?6m?^Ql+0ȣ`?V#`xG3lG"g `?XنE Ëy>l6| /}?6m?^Ql+0ȣ`?V#`xG3w d?HنEA j2 e.9.dA6\/r]?2m?^Pd)pȡv ?R" xC2AlEA"e ?HنEA j2 e.9.dA6\/r]?2m?^Pd)pȡv ?R" xC2AlEA"e ?HنEA j2 e.9.dA6\/r]?2m?^Pd)pȡv ?R" xC2AlEA"e ?HنEA j2 e.9.dA6\/r]?2m?^Pd)pȡv ?R" xC2AlEA"e ?HنEA j2 e.9.dA6\/r]?2m?^Pd)pȡv ?R" xC2AlEA"$Y3M,UI,r]?2m?^Pd)pȡv ?R" xC2AlEA"e ?HنEA j2 e.9.dA6\/r]?2m?^Pd)pȡv ?R" xC2AlEA"e ?HنEA j2 e.9.dx`~(1 u˹MUl9\]9gCDY~:pU\'[''=7j F#is-s;]TalY4U\Y㼗>=0.U^4oI~?F#LO?{I* EF?1ܦΗ*LZ咠F߃Mr{m /jk6_Rr\ DŽm۲cxD}|ܮRUɾ!}*z4/=v \uA{_zr[1-_|yoϖ_OcA{~f~*߉ZΠG=7I&U FhFoO)'3Z唠 #xޗ$n̠V97h$O¦>W>/j=>'}5IxQ6h͠uOH=bz,H[ǂ}s)O~/Tq#9g$i%Q?wjstg t[|awY~Y~Y~Yyf|Y,ebbWˏ3=f{-fy:5g7X5"vP&K: }/b -M@O>_'òpm7ckMuz>g|F=2cn;zT/+ٗVkN]둿MHY/Ӑ3HArh#w }osv澸ks#La~[wr(vh\mowOb:M?-n}릖]Gh|.x7ta/̊r΍+J6ӌ>_o#?k9~Ps2Ʒ^:O#-`FߙW T_';}?Eox~z2/TS \o㩓נy˽ŧv\MۺO/m>]ͱe]X57p=}nuMM}8z$}E{K;|cҾ;\[rӦ+6|,+|?WM+:(-s[GL/: ?9_3wbђ6hh~F}iaG/Q>K]]}u>Zf>ZQ/w>::d]}Bh }>:}G>>zGGxr>7їvGf}G>oh~hZ#wuYc1p:;am ͵F1uk1 ui.:j[bH]ywF.y݁[5{~˰XW/*6ws?QdO\#֠}Iݧ~z'>%מ4g}pU)AӓGz͐Dco?e׃ c:NM}znC7$o3IfH_r(  T Z0B%.http://www.apaldia.com/0 PPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000QPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000RPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000SPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 2000thttp://www.apaldia.com/resumenes/resumen.php?idresumen=1510?UPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000AVPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000CWPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000EYPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 2000thttp://www.apaldia.com/resumenes/resumen.php?idresumen=303xhdhttp://www.annals.org/cgi/content/abstract/145/1/1pl\http://www.annals.org/cgi/content/full/145/1/1fpRhttp://www.annals.org/cgi/reprint/145/1/10r+^PGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000s-^PGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000G._PGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 2000L.thttp://www.apaldia.com/resumenes/resumen.php?idresumen=4200A.aPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000.bPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 20000.dPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 2000/thttp://www.apaldia.com/resumenes/resumen.php?idresumen=430/thttp://www.apaldia.com/resumenes/resumen.php?idresumen=4300http://www.thelancet.com/journals/lancet/article/PIIS0140673607602347/abstract0http://www.thelancet.com/journals/lancet/article/PIIS0140673607602347/fulltext 0http://download.thelancet.com/pdfs/journals/0140-6736/PIIS0140673607602347.pdf0 0EjPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 200000NkPGrfico MSGraph.Chart.80>Grfico de Microsoft Graph 2000/ 00DTimes New RomanCPv 0( 0DarialNew RomanCPv 0( 0" DLucida Sans Unicodev 0( 0"0DTahomaSans Unicodev 0( 0"c  .  @n?" dd@  @@``_>*whoosh.wav.WAV 10103RIFFWAVEfmt ++data~~~~~~~~~~~~~~~~~~~~~~~~~~~|||~~~~~zvtvxz|~zvrnlrv||vtrpptz~|xvtv|~~zxvvvz|~xrlhntzzvrrpprrx~|j[QU_|bICCYn[ICY~zlnh]_r|]SUSSjz|x__l~v_]drnUb|nfd_]d]5=rrnj]jz~lMldrx[[_f|YQfWK_xh[zx[CIjzxxdSQz|_fI9WӹM;QnvK;OUx~xj]]YS~ɵlM?plM;CGpٵ[)Kh|% %;xtKQS]ɖbGr|lSnvz~nfS[nëx;Az=+AYݻ|=/1r_ ?|潄W5/Czãf)/pvbMQr|O=OtjdhjlG?G_ɊK3לdQCMppW;1SŷAMz/#?bx͖SAM[hvhYp~~zrvt[]ptWOUtxxd]v~vvxzd_xzh_nrSQltbdp~_lrQ_l][tf]W]~hWfp|fWhnhbU[hzlSCWbYbnxpdhjvjM9Ot]GQ[dpp~hhhdpx~xh]Yntnrp]dlvjQMb|vdjpzxzztljr||_[r~~jb_j|z|xpp~~v]Wh||zx|x|zzndhpxr]Yfntzjl|z||~vppnrzphrxz|~|xtrjjtv~~vz|z||xrrv~xrprtz|||vzxvx|xtx~~~~~~~zxxxx|zxz~~~rrz~|xz~~|vtx|zxz|~~~||zx|||~~zz|zz~~~~|~~||~~||zz|~||z~~~~zxzz|~~~~|~~~|~||~~~~~~~~~~~~~|||~~~~~~~~~~~~~||~~||~||~~~~|||~~~~||||~~~~~~||||~~~~~~~~~~~|~~~~|zz~~~~~~~||||~~||~~~~~|||~~~~~|||~|~|~~~~|z|~~~~~~~|||~~~~~~~~||~~~~~~~~L7carbrake.wav.WAV 201026RIFF6WAVEfmt ++data6~~~~~~~~~~~~}}}}}}}{{}}}}}~~~~~~~}{{{{{{{{{}}}{{{}~}}{}}~}}}}}~~~~}}}{yxvvuusqqppnnlnnppqsssuvvuvvxxxy{{{{}~~~~}}{{{{{~~~~~}{xxyuvxy~~}}y~~~}}{~~}y}xxuxuvvvvx{yy}yyy}~~~~~yy}xvvy}sps{{qiksuqgiqsqnlqusnpsx{{{{{yy{yxqquupnglpqpnpqsusu}}xxyy{{{~}}xxyxvqpqvunnqussssssqquusvx{~~{{}{usqkipniggkpvspsvuy{xxyy{yxy}~yx{{y}}~~{uvvvxunkqunlnpquxvy}}}vvvspnklkiilpquuvxyy{yuuqppnnquvxxuvvx}~{~}}}}{xxvpknpppuuqsslinqsusssxxyx{{vqppkilngablvupq{~{y}}vyuuqlkknpnkilllklpqplnsyy{}~}~~}xuuqqnqplfffffliklsxxxxx~~~~~~{uquupigkppu{}~~~}~}}{y{~vuvqqssv~}{~}xsspifdddfkpsv{~}xuuusuuuusvxvvxy}~~yuqifdddbaabfa^_abadfflkklsxvx~~~}}{yyvuvvvyyvvx{xyslgbgb_d_bilqy~~}{sv~}{x~~}vqqux{yxx~~}~~y}qx}sxx}yussx{{vxvupgdfkd__^ZZaa_aaZZ\W_bgbbgillns{{}y~ygabi\TTOPGGJKH=CC;CMJ>@HO^^_nqv~{{vvysnklqnfgpvniv{ulnspspgfnvqgilxyupquyysllpnklqvspsyyv{}~~xx~xxuq}qgkpxskkpqlillniggglibb_bfipppuy~~}~{xsv{xvy{}}~{~}yxvvpkilpnigdgkgd__gkkkfdfinnllkpnsvusy~~y}~{}upkklklklnqslllnnkkkidadiib\_dfiiiinvuxxyxx~{xxupipnfifdggfaffgipliiiffafddglgknpv~~unkpvysx~}~~~}{y}{nglsupnsv{{{{{{{~~yx{yxqquvyxuqqy}upqnvvx~}yyvvspxypqs{yi\^^YWPJKKMTY\^Z^ipssxqpuuusuppu{up~x~uǦqx}s^HCUP=..33+"!01+)18>JOT_nsu¾}vlf_UTWRJGJMTWRORY\UUYW^a^^bilkfadluqnusv{{xpifksld_fg\RRYbdWT^inliabgkgffdkibiqvqsx}~qnxsd\lvnYTagaYPUa^WMMRMKKPTRUW\_Yaknnls~xvy}}pilppkbdbZUZ^ZWUYZ^_a\^bdknlllqyyy}vvvqifadZY\UZURUTRYU\\UTW_d_\abipsx}}{v}}xpsxqukbgl_bgnigqqnnkflvg_d_dkdZUgyndaluliianxunpx˹ǵǾqqd_UOKC90=;03>CCJRUZYUP__UTgidpx{vx}{~}xnuuҸxdRRJ9,&!  '>;=Tlvxý½yppsxgUWWYMB=BRYTC66EJKKMMRWaa\\bgldZdqx{vv{nZ^lkWKHKJCB813==9CHC>BUYPRfnkq»{vxy{l\dnliffbgfWMMR\\Y\\^TR\dbZdqplv}{nyssy}~~}{~vquyvvuqusligZPRYUKHPWYY\abkilsux~xpuupnxqqnnnpnqkdaYWWPKKORYWZ\^^iknyua\nxupv~vy~}xgiqpkddffkiinnk_fnnq^ZnyibqsvyŶxnlvpfTKO^_WY\W\^^\\\ZW\^RP^b\WYadbbd_bigdk}~^vȶxffu_E835, '+!$9MRWdxyx~Խ~sx{xnggdWPPPH@GJHKRMGMWfaKRi~xbd{~ln¹¹}~{lbpqdRKOMC86335056BJGEG^pxux~~Ŷ}~~yps}yv~~}xu{upgbdb_\Z^ZY^bdpuu~xss~}xxv}~}vupkgaWTY_YMMZddY\gsxsu~}{~xy}xqqpvxsslpslinlafffnifpx}}~qdikbZUZYa_\inffsvssllpi_\iaMKYkpgTY~basöŽ»pn{udWOR_bJ;COYYPMMKC@MKEG;BPROU\_by}pxʾn\YOB60,$ !.8EPZdyʾy~{xuqlZOOCCORMG9=JKGJKMask^^daap}ó}x{yqy}qdWKEYRJY_TJPWRPWYafdb^anlgu~}yv{x{pln_R_iliaggafffgfblqllns{vpivui_^bg_Ublfb_ipkki_bfpnggip~}xnillf\YUJJKMPU_ag_^gu~~lfu{lTRlxiUECOYE>GGHKEMMZbZds}{Ǿugpyssifvsdddf__^^ZREMYTJGC_kPMi{kks{\yҾ}ugUEEH>'$')"'55,1=HHHKM\kx~}y~skia\adUM\YYgZEM_iaKJk~y{}gZZaaZR\b_ZZaafpkZbkgddY\nvvu~vnxy~~~ndgkknkpnklxskfkvpgfggUYssgiks}x~vy{~vy~~}npuyqlnsy}sknp}{qx}~vy~xpuxvqkqpgbbgngggkpqx{~{yupqqkad\TROUUMPRT_fZOYdspiny~lWWsbMGYqkWPTUWYZTHR\\HEWfnYRuxg{°qupaWMG8+6$"+'0356BH@CMUMUpq{xy}vxu~~silZEGOYUTYOdx{}x~y~vvxq\TfdZZ\nuigkpnnqvyyuux{v{uv}}upx~sdp{xvvnyyvqik}vbsxipubv~ysy~{{uvuq}uxuux{y}x{up{~vpqspkkllnssgW^bgqpqvu{~~yniys^JGbqaP56^iH@Y^xx~~xiuuiakqxsdgnuviTYbquiWUfZYqu^Yfafyv\iäŮͳusbldTEGE55@RUWYWTfu}qadikpdYdq_dynfnuqpk\gns~{sknvya\nnfg_akd^\ik_p{}}}y½ydfs~{nUTppbYYgnlkqpiluqvqxysyxpvy{ysl}{~vysilk_glgsuiu{plpngkpnqplpkbYTbiuqs}ys}xs{qsnklYPOfsZWdlxvi{{}{}un~{slv~qysnu}}gZ}~kqn~{pnqf_Zpxvvfv~~sY_qiRPZ\da\\\Pp}{uu}pq}}pu^aqsuniy~vs}i{~q{y~{~}}nknplld_Y^gb^Zdqv}~}{}{}y~~yxxnqkq~xx~y{yxv~y~qlxqlg_ax{snki{{}xx}sy}{ylgy}}{}~xss_lpgbZbiuulpsp}}y~svyganuyp\^pvsigu~svyv{~~vplqubqvu}pdnqs~~uvq^p{~ilqyub^fvsd\\\b_PHOTHYpsl^f{sbnvv}}ifdaaiiWbqsqlku{{qx{{v}vy{vuqdknvupqxux~~~{}{qpux{vsuqqssvu{uxyx{{vx}{}}yy}{}{vxvxsvuqqkinnkkisyvv}yvxxsnnspnqsxvuux}~}}~}~~xx{}~xnnquxvppssu{}y~~xux}}yx}~}~yxy~yyxpsvxxuqs{~}yyvyvkiffgfgiiikkfilkfkpy}}y{yuuvqlgiiggkklqpqsvxysv{{xpgkqsqvvvvsspqxx{uuy{sssp}gZ_dp{us}upk^RKd}sgvk\^ny~}qdbix~fPCMfsuslbpii\M{ykYa}dvTa}^g~lGba;>UnlkKO^{kP^akv\9HfOTlqE;C=\{G^g{bGZ¬nPikPTqUs{aTUl{¸W>KaMTx>G;Kg80TpxB)KuyqdPZxǕuglp§TllE09O^uqlfG3K^Ug}ǸsPWlZCRgvö}^PW\UbpsWWYC>Kas~W=EEqff͹bn_qTHbg_M_qxT61Hfvp”RfC6U{i^~xJKk_@CZl}ùZ^}RBRfyçisZ@Jf}xծqxiCYuP6Jlg9UxuiqbJ3HgaWk¹laidsyǹvdB)!&3WZYu~}bJ95EgZWvŹqdvbGBKi}kK@RM}vnŗ{uJYqG9K\{qgT89TRMdy~pgZGEUZkԾuB1B@asWPl\=GRig\nZJpuTERk}˸nYsg@3CayybusP9CHsv{ʶnvJ{q{R>;pKsŦv9Yl_HuGRvKYOJlplvnl_dvˍWpȩlC\xvu^d}qBHOidKJi}\ulgig~{ȳpCun\~}BWuC.Ck;=ZsG8Osn{xu}pOdbORflyfYYaZ356J_lûlMbWTduxȾ—_iROHRi}Ƚ~\dC^i^Y_Uiudzd_qu;66^~k\_y~TGGkd=)9TgžԽuEpgOTp˅Z~ÙWbZ6'1JfffJ9Jb{}b;=gpunnű_g}kKP^x͵ulxiZJ;KTp{ňxqC>;~Y5JJ~guJ+ig>HCT@avԅ{¬sskPUqʾa@6=BZixŸ{~d85KaGK^vxsPEgyPZvжiO059GZZp~ylaM+$>Uk}ŤsiPaladsŬf8CKWaB;MfnqfE3=EYbp~dBETqg_sň~yf\p}as{lR;;TTMZllM'.ZYBHT}yY@W\uv϶fBOYYJ\}\Wnu}__E8Jbu}ŮRPygOfKKgyȱgU\bp^yqB58KGMbyvP;MWnYnǜU=BaaPbpYlO!)d}=MfnHGYfϧY{vM9\E\l{WniYaPa\}xM$MiEyuygȳqdH6Gqbu}xUq96TE.Rbf{Y}Zq\u~paqv_CCUnfaTi}T9HxTgg{Ȟ\dslnU{MdxgÏOWx_{iuikRk}gOWYWqsq^=8EiMps>anU9,6Zk±^^vsxnRKfy¦lMi{d\U@0JbubJqvkxb@@OWZW}s{q~\H{yUdpWMixMPOgiJsK>Zn_}yklYabZvs_ZYH\i_k{~nP6=U}}{l~dGG_yxbõu~M=Yn{pyqZaY66G\{}qiaM>Rk{NJUg}vfW@.3C^fslkgfGuWfUlx˙ͱsUa_;>Pndsg}lYWORCayvv}dOK>Rafq©ldvaREKdp~Ⱦ_ygRKH__dxld{vnqgUEgYlaagYJnu\9OTCfyf~fdf{»n_RW_Z6EEJ_p}xkG=;ffšpB+B}saZsŸ_5PlifRdyl6=yJKWky˻qU8UpPWf{¹xfO3+@TbqvxlaJ15Rnd_{öǹ^OTubxyyʳ~l\C6Kpqu\vnW.3lkZbv~ydC5T}YpqP3@Zx^pq}siG&.E^}p}«~pMRl{GWs٦\Yqf^ZfsxJ'GM_Wql{\36q~iTiʻfH1B\p\~ùg@,;TgPl{xkM,Gi\Y{axqqqfa\T^YivkWaUluagyukf~ulUKp{ZniYKbyqHRKJguxfdaUUWb~~yypyqiYKPduödi_^^b_U_snO@EUku}~kM39;GWiuvdHUTYalpȹlHGd^\dx~kE&B}fRMkxkM9Epgký}pdYB8P~lfЩpdWG05O{abangM,Bsa^uȻxy~ZHP~kMTn~ëvv_9)dfasufuеqyRE_nxqdP8Eqgf{{gOHWYTkxq_WkgdxsisZnpfanl{{qkUkifk{g^}xqnbi\u~nHn{l\qu}u}xP@y~viuxsgqqvkuY@HKduǾ}KOk}_\TWguaYUnsOH{gffds{¤vxpfvZ\{ngbPHdqvxvd_xukWp{susdU\_RRqpdKOfÊi{iY9O}u{v}f{pW@@\lynvxupx~n@6RsUugdUWa{vß}vuO~\akg_lDZgg1Ex}KOqxuM@akx\qaa~lPYfU\v}y~}qakMPq{d_Wp}~iYksg\y{}6@s>>bqG_lqunTkp^kayaqqluvf^Tisvdqn~xiskZHk^vx}~vbqlWqq~_~qdqqaGaivn_RY^b=WiUpiR_\MYxyqgxxvuffuJBPng~Z~^8=\{{l~âuqqlkxfqqqlbqgxuu~~Zinfgdlvl{suvvsyP>;bs\ya}ZZbb^qRdyKBv{~}x{GM{kqZuf^TGEkki~xnfsMavU\yZM{palÏ_pdx~qUUdbf}~~y{udMs~dx{}}du}yxsbPfq}}ngxklnRJR{iRk}nBa{vYpWnubk_^ypk{}{i{qdvy{vfYWR~k}U5Znsxp}udapx{~~}qgfyxKTxk~uRanPOguJOdbnx}iWpuqZ_fu^~}i}sgki_pykslxuqpkxaas^\sxud_x~vW~_i{~pgxq\JZf\PqxRbqunWkiyknvsugW_vksn}{pklppa}qWf~ukGYfkdppfUk^\pnxq@;xdYvunnd\pqxsfU{qndssqyvZpvyybkkpkgau{v}xlbMCT_gppq~}\UnfYi{~}bZsnZWxiukdy{~fJasukJZbnd~qYkifi{\K^uxubTk~p\kklPJabaxaf{~~svUv{ZWis{plu~bCJ_nnvflfdv{}gM^}u}}x{~}uyWHE}xd~ZEMg}xk>B}nqupgsMnMRkskn}s_R9=OZ_\usgKJnsanfiJYdgT\Wkv~p^^lu~qkU>BP\gnivvnl^PEYddid_g~vp}x~ZRfvpsu~usvRkTP^isuiv˩yy~qgWEZba_uqfdibTEPguȰ}nqZCBWgvͶnkavYKT^yuȫfPp{kigqlq{iy^OUUfv{sTTdaUdqk^KRTn~î}lsTfxsYp{Y_{^EUWUi{uvg}d^Ydin{n_KP^iRav~udRZibi}sifaUHZnba~kTPnpy~_x\yORviYsx^YfygZf}nx}pgZP_q~nxlda\KHWgxknibfdbuydO~~iZi~nkZs{vqYan{}pdROfkxk~nPZuynl}y}v_aRYlyixq^pyU_gYiy^nqaf}_Y{WYg^\~U^pggaUssYl^Zq{fl}a^p{fx^Zni\y\Raxy_yyPTklnaTp{snZuvaxv_dysykgxy~ub\bsup~{niuylnpiqn}sb_n{qsysunvy}xp{{~~ldiky~y}kfnqqynpu{lbgy{s}kgvxp}}llpqx{lfgq{yuxyx{{qpu{vnv}skuy~vp{~vsqnv~vvssqv~y{unqyx{ss}}plv}pluy~yy}xllv}}xsss{vnqyyuux{yy{ysy}~}}yy~{vsqqsx~xxy~xqqx}xy}uppy~xsv{uv}{y{}y}~~~~{y~~yxy}~}}~~{{~{{~{xy}~~{vvy~}xy{{}~}}yxxy~yvy~}{y{{yy}~~~}{}~~~{yx{~yy{}~}{{{~~{{}~{}~~~~~~~~}}{{~~~~~}}}~~}{}~}{}~~~~}~~~}~~~~~{yy}~~~~}~~~}~~~~~}}}~~~~}}~~}}}~~~~}~~}~~~~~~~~~~~~~~~~~~~~}~~~~}~~~~~~~~~~~~~}}~~~~~~~~~~}}}~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ P)U   ;  P+sZCU 4  3@)#=c6N3!Rl +; M.+ - =3a a      a  $" &r<dH  5$'?98\ <s    :~L / S   T ,>+     b$s#ڿE`"  `b$$>I$ `b$-gB4nyө* `"$.efc zRt`$`b$n ʚ;>7ʚ;g4BdBdv 0vpp<4!d!d` 0LDP<4dddd` 0LDP <4dddd 0LBg4=d=dv 0.p po___PPT9%hlpL.//00 0z? %O =U2Es el etoricoxib un inhibidor de la COX-2 seguro?33fff " Antecedentes (1)_Los inhibidores selectivos de la COX-2 se introdujeron como una alternativa ms segura a los AINE no selectivos, con la intencin de reducir los efectos adversos gastrointestinales de este grupo de frmacos. El aumento del riesgo de eventos cardiovasculares asociados a su utilizacin en algunos ensayos clnicos ha puesto en duda esta superioridad. ``TAntecedentes (2)?Sin embargo, en estudios observacionales posteriores se ha comprobado que el consumo de algunos AINE no selectivos tambin se asocia a un mayor riesgo de eventos cardiovasculares. No se ha comparado la seguridad de los inhibidores selectivos dela COX-2 con los AINE no selectivos en combinacin con gastroprotectores. @? ,  ObjetivosValorar los efectos del etoricoxib y del diclofenaco en condiciones reales de utilizacin (congastroprotectores o con aspirina a dosis bajas).>  *  Diseo (1)Ensayo clnico. El programa MEDAL consiste en una serie de 3 ensayos clnicos diseados para que se pudiesen combinar sus resultados. Criterios de inclusin: e"50 aos con artritis reumatoide o artrosis que requeran a juicio de sus mdicos tratamiento con AINE. *kka Diseo (2)9Los participantes fueron distribuidos aleatoriamente a recibir: etoricoxib (60 o 90 mg/d) o Diclofenaco (50 mg/8 h). A los pacientes afectos de diabetes o con antecedentes de enfermedades cardiovasculares se les recomend el tratamiento con AAS 100 mg/da. Tambin se recomend tratamiento con gastroprotectores (inhibidores de la bomba de protones o misoprostol) en personas con alto riesgo de lesiones gastrointestinales: >65 aos o con historia de lcera o hemorragia gastroduodenal o con utilizacin simultnea de antiagregantes, corticoides o anticoagulantes.\@Z7Z4ZZ@74%   +' m!!2 Diseo (3)uSe visitaba a los participantes cada 4 meses y se contactaba con ellos telefnicamente entre visitas. Variable de resultado principal: desarrollo de eventos cardiovasculares tromboemblicos. Otra variable analizada fue la presencia de complicaciones gastrointestinales (hemorragia, obstruccin, preforacin o lcera pptica) identificadas durante el seguimiento clnico. vZv,j B Resultados (1)PResultados (2)>La misma reduccin se observ en los pacientes que estaban en tratamiento con aspirina a dosis bajas y en los que haban tomado gastroprotectores. Hubo menos abandonos por efectos adversos gastrointestinales y por dispepsia en el grupo etoricoxib, pero el nmero de abandonos por ERGE fue el mismo en los dos grupos. ??,[ HGResultados (3)La mortalidad total fue similar en los dos grupos. Tampoco se encontraron diferencias en los anlisis por subgrupos. Los eventos cardiovasculares fueron ms frecuentes en los pacientes con enfermedad arteriosclertica conocida.  ConclusionesELos autores concluyen que: el tratamiento con etoricoxib produce menos eventos gastrointestinales que el tratamiento con diclofenaco, especialmente a expensas de los eventos no complicados y que esta reduccin se mantiene en los pacientes en tratamiento con aspirina a dosis bajas y con inhibidores de la bomba de protones. *++,- @ gComentario (1)Los resultados de este estudio demuestran que el etoricoxib tiene la misma eficacia que el diclofenaco, pero produce menos efectos adversos gastrointestinales que el diclofenaco. Sin embargo, estos resultados quedan empaados puesto que no hubo diferencias enlos eventos no complicados. Por otro lado, no se aprecian diferencias respecto a los eventos cardiovasculares. Quiere esto decir que el etoricoxib no incrementa el riesgo cardiovascular?ZP0  ?  )TComentario (2)La respuesta probablemente es no. En varios estudios observacionales se ha asociado el consumo de diclofenaco con un mayor riesgo de presentar eventos cardiovasculares. Por este motivo, la FDArecomend utilizar el naproxeno como comparador en los estudios en los que se estudian los efectos indeseables del los inhibidores selectivos de la COX-2. Al no haberlo hecho as, se ha perdido una gran oportunidad de demostrar la superioridad del etoricoxib sobre otros AINE.ZP5 j  /l345678= > ? BHQU  ` ` ̙33` 333MMM` ff3333f` f` f` 3` >?" dd@(|?" dd@   " @ ` n?" dd@   @@``PR    @ ` ` p>> !(  #  6ԙP "P<$ 0 P k7Haga clic para modificar el estilo de ttulo del patrn8 8i  0P "<$ 0 P kHaga clic para modificar el estilo de texto del patrn Segundo nivel Tercer nivel Cuarto nivel Quinto nivel7    l  S fAHI:\Apaldia-Usuarios\img\apaldia.gif"nP %!0  6Pfff "  /!0 uIAP al da [ http://www.apaldia.com/resumenes/resumen.php?idresumen=430 ]J:  t   H  0޽h ? *Diseo predeterminado0 P +(      0 O3   R*     0  3  T*  d   c $ ?po  /   0 e @1  kHaga clic para modificar el estilo de texto del patrn Segundo nivel Tercer nivel Cuarto nivel Quinto nivel7    l   6 O   R*     6\    T*  H   0whg ? ̙33 @@(  @ @ 00 O3   @*  @ 08  3  B*  @ 6D O   @*  @ 6l4    B* H @ 0whg ? ̙33"    0 "b (    s rAHL Y?I:\Apaldia-Usuarios\img\apaldia.gifP3  c $G`0<$ 0    6Ifff "  /!0 uIAP al da [ http://www.apaldia.com/resumenes/resumen.php?idresumen=430 ]J:  t     <Y  00 <$ 0  q  0^? ?" `  ,$ 0 ]Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP for the MEDAL Steering Committee. Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet 2007; 369:465-473.@^ R$6;    c A`C:\Inetpub\wwwroot\Apaldia-Usuarios\img\PDF.GIF e @  0!0 ! c A\C:\Inetpub\wwwroot\Apaldia-Usuarios\img\R.GIF P @ 0!0 " c A^C:\Inetpub\wwwroot\Apaldia-Usuarios\img\TC.GIF B 0 @ 0!0H  0޽h ? ̙33  `P(  r  S P     S  <$ 0  H  0޽h ? ̙33  $(  r  S (P   r  S   H  0޽h ?   L\(  Lx L c $X$P    L c $$%<$ 0  H L 0޽h ? ̙33:  z(  x  c $2P     c $d8Pp<$ 0  *.ZH  0޽h ? ̙33@  (  x  c $,FP     c $tP<$ 0  0.ZH  0޽h ?   |$(  |r | S WP   r | S 0X  H | 0޽h ?   bZ   (  x  c $cP   *   0 z p,$D 0 Participaron en el estudio 34.701 personas (el 72% con artrosis y el 28% con artritis reumatoide). Las caractersticas basales de los dos grupos fueron parecidas: Edad media: 63 aos. Un 74% eran mujeres. Un37% tomaron aspirina a dosis bajas durantee"10% de la duracin del estudio. Un51% tomaron gastroprotectores durantee"20% de la duracin del estudio. Casi todos, inhibidores de la bomba de protones. La eficacia en el tratamiento del cuadro articular fue similar en los dos grupos. Z  S Q,wH  0޽h ? ̙33  ]U@ (  x  c $P   ql    ,$D 0  HA 0?   0  <?" O* Diferencias significativas   <?"P  = * Totales     <?" `  ? Complicados      <e  <$ 0  H  0޽h ?   ` 2(  x  c $<P     NA  0?  8  0$D 0  <p  <$ 0  H  0޽h ? (    lh(  l~ l s *<P    l s *=<$ 0  H l 0޽h ? ̙33   P(  r  S ܸP     S <$ 0  H  0޽h ?    P(  r  S  P     S <$ 0  H  0޽h ? U0 @D(  DX D C  po    D S X e @1    H D 0whg ? ̙330 pH(  HX H C  po    H S   e @1    H H 0whg ? ̙33 0 L(  LX L C  po    L S / e @1    H L 0whg ? ̙330 P(  PX P C  po    P S C e @1    H P 0whg ? ̙330 T(  TX T C  po    T S U e @1    H T 0whg ? ̙330 0X(  XX X C  po    X S p e @1    H X 0whg ? ̙330 l(  lX l C  po    l S  e @1    H l 0whg ? ̙330 p(  pX p C  po    p S  e @1    H p 0whg ? ̙33T0 t(  tX t C  po    t S < e @1    H t 0whg ? ̙330 (  X  C  po     S a e @1    H  0whg ? ̙330 p4(  d c $po    s *e @1    H  0whg ? ̙330 P4(  d c $po    s *e @1    H  0whg ? ̙330 (  X  C  po     S X! e @1    H  0whg ? ̙33rxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (y?:R e]rxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (y?:R e]rxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (y?:R e]rxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (y?:R e]rxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (yMeG@XiDrxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (yMeG@XiDrxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (yMeG@XiDrxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (yMeG@XiDrxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (yچ:9K1#T@C~)rxp^RЀ3ÿ lHbP  @AL G@;b bW< ]P^b (yچ:9K1#T@C~)tx}l^'~!da4Pc^j q14IK0`lhj4(mMhgtኒ*WrQ$.#U9UUT^1#TE6yvKg L7+L9?l1(|~bb6<{ވ>4!HKu:e0!#E J Y\,D>,BAE>#! ȍMGNfVd1B>t#!=H/rr'1diuck ~߷' f|ሩ͋ M9;j6yf㎿̝|'NM9fybVԏs]aj˿zl4ެ9O@ڦ|⇪X6SƲi?iY,K~.s% Y|rk ]{9t,[rK^cK0)CDu,}-6ߏu3ylc<5bS[_GVTϩn:R}`̦W]݆ɷqʑq܃3fבO.3nLqs>6Zi.ܻp/.8WeXNr k0߾,x8=>՗ U}x\Peߠ%˖0u zeCP^?_?]tAX~/jEvT2t]ߧ x>Sh2UNW. ;gs_HK HdK\W\j[3s,Ջ#бsI@VL@gTR9نSo959>fknB&izfo 8[-\"; 9{/Ļmf^֝H 8C>4p'Aَ)vzYkJU[V:iխ~+i Mz[ـ$۽xpޘ>Wv쩺3ɺGܾ<>-:Xm[I'ۑvdlێڃ\khvdKhT?rn;sk-̻qʼW@^_gMSǷ^|H\>cNJ2Yt My)Jfϵڦ$ۗk ut^{4uɶ<4vO} L7ivfZj׹vIG,؜.W^hQh)͕x9/avv%1Wk{˪Mu?];.-uhկ/nq-=oV|3x׏~[b?6o(n~ 4Aڗspa4iwnnFM)7TO&%f*;8s۝M]1L>9~/Gn&Ϳ-oshF5=osПshϿY,".~|oocǩ\{?fcؘG?cg?.wr;UꑆS;c1M!yG~"-gެnh=۞bB,א wH?ߙ=_>;\Oo{);nyO=wsαӕ.gs]tV[ˆ>c飇֏7O)b>E6 nM.e~ "F] ߦQauu)bTU>C1*fapkmv-2(6E Ǚ}F"Fff7)bTaf0V"F6f)bT1f)bT؝~/)bTqfeYpmv7`"F })bT=̾1*^f_b%pmv?e1*f)bT؃V;dSĨ?wئQa3cf MaUf_wԦQa2;fSĨǘ=qp'l?cgN1*If_gupl`N1*if/)bT3_;kSĨg}76E 2fMžcwy"F=lΩ9r'oSĨynM6k)bTn2{)M]lBf[dSĨ3æQa;M:mbf)bT.2צQa{ Rpmv\A]ϦQa l?6E R̮ڦQaW5lv@̮ΦQa61*2ܐMapMzrev+Q"F+(cv1*2."F%WPjWsHk%[z+KLM3ziKR]إܴ%fM. no M^bV٤®]/gmJ.n&Ev-7zYo vlIхM^bmRtaiKV]حܴ%f&EvvIхM^bmRtaǹiKn]ܴ%&Iх iK]=ܴ%fM.^n&Ev?7z9` {vIх=M^b٤]/1mRtasӮ#6)GiKQ]أܴ%M.1ns&E7z9i {vĜIх=M^bNۤž]/1glRtapӮ6)giK@PRtaiK9]sܴ%M.ynIх^b%&EYz)ؤծ6]6f%fM."f%&EYzIхdV^blRtaծ^]^f%fM.rf%&EYzYi YzYm YzIх`V^b٤®cV^b6ؤn`V^blRtaծ&EcV^bFmRtaGծ6);ծ]6)WflvE3]1?&Gх]M]®.Qbtai`r]UܴE09J.n"%Fv-7mwL &GхM]sv(1[i`r]1n"%Fv'7mwL ;M].Qbtan"%Fv7mwL &GхM].Qbtarv(1i`r]ܴE09J.n"%F(7mwL {&Gх=M]ž.QbtaOqv(1i`r]3ܴE09J.Yn"%F6.Qbtaqv(1i`r]ؚEuv(1-j`r]"%FYmwL YmwL &GхdV]v1.Qbta{v(1˙v(1}j`r]ؕj`r]j`r]fE09J.:fE09J.fE09J."%FcV]Ž2.Qbtaw0.Qbtaw1;v݅3]T+nB.RnB. nB.l?7mw!LRAv7mw!LRAv 7mw!LRAv-7mw!LRAv=7mw!LRAv#7mw!LRAv&G &G ;M]TЅM]TЅ.Q*.Q*ܴ݅09J]=ܴ݅09J]ؽܴ݅09J]ܴ݅09J]ܴ݅09J]؃ܴ݅09J~ՈCܴ݅09J]ܴ݅09J]#ܴ݅09J]أܴ݅09J]cܴ݅09J]ܴ݅09J]ܴؓ݅09J]Sܴ݅09J]ܴ݅09J]3ܴ݅09J]سܴ݅0vMŦܴ݅09J]sܴ݅09J]ܴ݅09J]ؚ݅uv(ta[v(ta j ar mj ar v(ta;v(ta;v(tav(ta{v(ta3.Q*1.Q*®dV]TЅ]ͬ&G ;&G Ymw!LRAvB.B.Ǭ&G ;ʬ&G Ymw!LRAvMow>۝?09J3ziar]إܴ09J. n|%@;&G Ѕ]M۝®·Qtarv(iar]؍ܴ09J.07mw>L ;&G Ѕ·Qtawrv(ܴ09J.nn|]Xi|%@b7mw>L ;&G ЅM۝·Qtarv(·Qtasv(Giar]أܴ09J.1n|%@7mw>L {;&G Ѕ=M۝ž·Qtapv(giar]ؔ;&G Ѕ=M۝ž·Qtakvٝ¶0·Qta jar]6f09J."f09J.l|%@Ymw>L Ŭ;&G ЅeV۝.gV۝1·QtaW2·QtaW3·Qtav(v(v(Cjar]XYmw>L ;ʬ;&G Ѕ;&G Ѕj۝vhwLRF/3zi`r2Ki`r2+i`r2ܴy09J]Uܴy09J]5ܴy09J]صܴy09J]ܴyS=؍ܴy09J]an<.Vn<l;U#Ƹi`r2;i`r2ܴy09J]ܴyQܴy09J]=ܴy09J]ؽܴy09J]ܴy09J]ܴy09J]؃ܴy09J]Cܴy09J]ܴy09J]#ܴy09J]أܴy09J]cܴy09J]ܴy09J]ܴؓy09J]Sܴy09J]ܴy09J]3ܴy09J]سܴy09J]ؔ;&G) {;&G) {;&G) [;<.l <.lYmwLRFYmwLRFv<.l<.l'<.l<.l/<.rfy09J]>fy09J]ؕj`r2v(etav(eta1΃Qn`V۝хbV۝хv(etaGv(etaw0΃Qbv\esg;&G)=ܴݹ09J ]إܴݹ09J ]ܴݹ09J ]~n\`#*n\.n\kbrv(%tasv(%ta7rv(%taisar[isarcܴݹ09J ]؝ܴݹ09J ]qn\.nnofKܴݹ09J ]=ܴݹ09J ]ؽܴݹ09J ]ܴݹ09J ]ܴݹ09J ]؃ܴݹ09J ]Cܴݹ09J ]ܴݹ09J ]#ܴݹ09J ]أܴݹ09J ]cܴݹ09J ]ܴݹ09J ]ܴؓݹ09J ]Sܴݹ09J ]ܴݹ09J ]3ܴݹ09J ]سܴݹ?.lM۝ Ѕ=M۝ Ѕ=M۝ Ѕٝ[gw.LRBYmw.LRB;&G) Ƭ;&G) Ymw.LRBYmw.LRBYmw.LRBYmw.LRBYmw.LRBv9\.l\.Jfݹ09J ]jsarjsarv(%ta70΅QJ1΅QJzjsarjsar;v(%taw1;d{y]g~vt<`>g̋W]hLѥv7^mz^2^9Viy봚yjGXigvG nyrhp}9:V{g{mVCh5V,=:jMb?[N[8ݕcf:ߴt[}y\OKsOfO7;zkձ;؁R;v*uw4ԏ]כֿ_;ի?n]N${r\jO MS.f滏>zWz_Hx?zs.wa˥,/]Y]~$^>O#Hҍ1oi;[mH.y7rYY܅!w#EAEއ,EHY܏#,G@V +$<Y|E!l;2<ݯun'Lb_ގ{!z uܾ#"#>f?X(n2sα%˗/WocMfb_7p3R ܟ~3]M?p߱%`qݽoX䦾l~8y%:+{wE`}x{1ijGq|gDz/ w >s.X3>3̦Kጋ1_Sm,G7.i4Z#\Q#x~p.ޮc&/㨛]<36 #{m/O('׾/3׻iƵ^;]=3L΅e?ȿsuG{Yrfo?ܔ}},O_};D_b*}w=Hvぼz|99xLο@EW+?AQ)o'__S&_?sǏ\կ맣eGE׻GrWp}[96Vbk2K/f̭<0_hV"|0[b!s]mK$]ȸ8uI{3 sbۖ/l܁hYk_ڣQbhƠw=7oH{Ov{å푿G6ID7=Jl *=hoxo >8.ho7w}gF뫺]>O(mo:MD#sop|)醃`ݷ>[^^;Sf)$fwB:wQ:pKf> Co/㑺 ^4{g4p q=R2i7C8{lcd ADJOcDzGS豁ҟۘzCY׍mn?Iy'2 ]n_ӋgqOH~$p?;nf?7{̽ls/pio{!^>^5HvW7:.s?K'{xo<7eeE|i5EK8" ڟEkLZ=~Mz,,ts]dXtsz `xk4ງq]+!5tczry"ړ6v^C!} @}V+P9mUǬX>o9$]x}ω\.L>sL}~I\i}0Qv/O]%$J |ȾnO]l_$EpU UWȾO]كl}! ؾB+TЕ=5_wħ:>te%_F{gs^,~t%w]J.s_?D_ge}q\ׅܼ_+GPW"nABV.-Oת_ u_Z{>sS>`=:mvE5]/_@r?2g}pen7ڟDS5Uwڏ&xds=B<ιX@/i߲-/w2,wnKNonMt& VIȟ%=M^tgn$E,?DC}*;L O[STٵd&4>EL]O#d?nOSe7ُSTdȎ)b8dSTd'N)b$ȾnOSewunʧSd?C31Uvϒ,>ELKHϧZ 1Uv?Yk#AէU0F>EL=HHpȧZ 1U0Yk#"!k c$8ST٣d_':OSedA1Ud;STd߂;STٓd߁;STSdKN1U43>EL=CdOSeϒ}1U7ɾ OSeϓ)ٟST dA& ST$['Np>ELf2>ELͰ-$\OSe{M1UvK1U^[ST٥l.ST~dW)bۃdʧ&0A"+(!pk|*F_Ak)b숾]:"ʮWP>EL p}*Q_An7STQb9dķT[L$9P okm% 30Uv,DTٵdda&ʮ'km% 30UvYk+Y$Z[L$9L'km% 30UvYk+Y$dda&&km% 30Uv,DT=dda&%km% 30UvYk+Y$Z[L$9LHr*{,DTCdda&&km% 30UYk+Y$GZ[L$9LmHr*{,DTdda&ʞ$km% 30UYk+Y$Z[L$9L=CJf"aYV0ISeϑHr*{,DT dda&&٬da&vY[L$9LͰY[L$9LaHr*Jf"al,DT٥lV0ISe٬da&Y[L$9L]fm% 30UvJf"a6k+YKr*;fm% 30Uv,DTِJf"aF6k+Y$1ORԼ~HҠA|!I ."Ic0Y')$kZ?IE$iL]OI ."IcORpISe7~HҘ*;NI ."IcORpISe'Z?IE$iLMI ."IcY')${Z?IE$iLKI ."Ic>ORpISe~HҘ*[%k$1U Y')$Z?IE$iL=LI ."IcORpISe~HҘ* k$1UY')$'Z?IE$iL=II ."Ic)ORpISeO~HҘ*{\DTٳd"4ʞ#k$1U6')$K٬"4Y?IE$iL`~HҘ*I ."Ic \DT5lORpISeGج"4ʮc~HҘ*Y?IE$iLf$1UvԴVvi?i!zb~t>-te٬4Zk٬4z٬4ج4f٬4ݸO ]q6'Mç6'M7BWvIi+IMЕb~t{|Za~t{}Ze~t|Zc~t}Zg~tUU6'MwЧA6'Mwȧ!6'Mwاa6'Mwħ6'MwԧQ6'Mi+`~t|Zc~t'|Zʞ`~t'}Zʞd~t|Zʞb~t}Zʞf~tg|ZOLa~tg}Zʞe~t|Zʞc~t}Zʞg~t|Z^`~tI4i+MIe|ZfZ?i=d4"Z?i>}d4RKZ?i~d4݀O ]OnO ]Ud4ݠO ]AOnO ]5d4݈O ]OnO ]ud4]BW6$k6ЕHIӍЕ 'uI}^?E$ t!6'u0:\D@Wv-:\D@Wv=:\D@Wv:\D@Wv3:\D@WvI."i+I."i+;f4Еf4Еb~RHa~RHe~RHc~RHg~RHV٬"٬\ ~RHf~RHa~"< [?4Еf4Е8f4Е=f4Е=f4Е=f4Е=f){I."i+{I."i+{I."i+{I."i+{I."i+I}"d"OpI]OpI]Ed"}d"KZ?E$ teZ?E$ teZ?E$ teW~RH~RHʮ!kmذ#d"Z?E$ teCOpI]ٍda J?'U^-جT"lOpI ]ٵlOpI ]lOpI ] lOpI ]lOpI ]q6'U6'U$*\DRCWv7*\DRCWvI."+I."+I."+I."+I5SCWf Е=f Е=f Е=f Е=f Е=fD MRCWf Е=f Е=f Е=f Е=f Е=f Е=f Е=f Е=f Е=f Еf Е:OpI ]nOpI ] Y'UlY'U"OpI ]>OpI ]٥dT"dT"dT"Z?E$5teZ?E$5teא~RWY'U:OpI ]ِ*\DRCWv#Y'Uhmn?)OI."/Y?)E$te٬" k٬" ٬" ج" ٬" lOpI]lOpI]I6'en6'e2\DRAWv2\DRAWv/ۿ}p]/l TЕmY?)E$teY?)E$teOY?)E$teOY?)E$teOY?)E$teOY?)E$teϰY?)E$teϲY?)E$teϱY?)E$teϳY?)E$te/Y?)E$tec?)2\DRAW2\DRAW6CI."+CI."+2\DRAW2\DRAWv)Y'el?Y'eY'e*OpI]AOpI]5d" #d" Z?)E$teCOpI]ٍda $IK.")+;f$HJʮe~E$%te׳Y? "جpI ]lOB8.")+IЕd~E$%tewY? "SlOB6'!\DRBWv/.")+IЕf$HJV٬pI ]كlOB!6'!\DRBW0.")+{IЕ=f$HJ6جpI ]clOB 6'!\DRBW$.")+{IЕ=f$HJʞa~E$%teϲY? "جpI ]lOB6'!\DRBW6ppI ]nOBl.")+CIЕ]DIЕ#k$HJ.%k$HJ~E$%teZ? "Z? "dpI ]5dpI ]OB:OBlHIЕHIЕ 'yI~^?E$o1f$Еf~H ʮe~H ʮg~H n`~H nf~H ʎY?E$tewY?E$te'٬"٬"SlOpI]=lOpI]ٽlOpI]}lOpI]lOpI]*<\DR@W <\DR@W<\DR@W0<\DR@W<\DR@W(<\DR@Wf$Е=f$Е=f$Е=f$Е=f$Е=f$Е=f$Е=f$Е=f$Е=f$Еf$Е$?OpI]nOpI] Y'ylY'y"OpI]>OpI]٥d"d"d"Z?E$teZ?E$teא~H ʎ~H ʮ#k$Е Z?E$te7~H ʎfSftk3ܬa,9?UNڭ^CF81?%eY3릋gMdzxYwxV6UųaZޖ3p>?Kޖ߽_>?;ޖu~Umy*zν-<ឹN2L3Ռ3dYk5OO½ŷS\5]>=2Ϲ7x-snM'wSi[~0Ϲ7#=-y ɿr]_]myesCoU7"w]mЛ|ޖks[̟}U~e bܯ2*?1~E;&Bnɝl41msvmM[w$CuvwO =tO2v_vٟv/scc|عL3c2*o]Gb[u9c> =۽Sxo5sī4{-N˟JWPOI7An5i7YEk?v(n~)I#:wFiR|Wx,=86{м{^'#qMݓ=~O~{R^)7\:ً]g/^itڵ߁4z,{߄d\'}G@W}Y!Ql zxpyƿ=v%a@e"d0Ƃ·f06ƎL=+! %nLII;&ئI屻'd&$)θ$M%X}ow=tB4O<~}o[N/tꙩ?2nLyk޸$Fc2۷ߩo>$>:j&@)nr|KK&2h  ]t%4 @WA3,h6NZht ͅAڠvh>t|F&ha2o巻|b_jSASyj2~4~693WFq6Gէ5lk߃يql4Q 9l'~SA=aM1OfG?8o%ϛݮɚeoЙ)CSwgGNMC| ~ӹ-۶t,ٰ6{rY$sﳏ{Czz-0oh^0_CGƮ<֚k~{.W3M˶gf̙mk[fl0cڹ,Z1ݽy1p^2-{NU/Y.0f9-usQ3ЅusetyKY#붮];gQ{Uvdj- >76t\e\G{ځ-y:q G~>ڌg{hO8n({Vo߆]qv}jo6BM7'q`.ۢd?c6_i{$>wE?zM}bs{|%=P~:A3cdk >{o=z <x93gkt{gͫ?>J7}G>g{>3kG(>2kٻw/z>+cY6N*^Kݘ5N)3,351m~u.z_#e:iךoL^:Y3)=}Ԛ;6oۼ-k3}:, ҵ l.v7[{lna`L-.9CKRbq6?dk7$%_o{_z9)?D/RK֟PYդdi]Ǔm~: O{ŖV#.fBd_6Z-t%퓒ڈo& IRRQ_1:#MJy',hb+)eel/Klڤq&YF&i1:Y\3qܮd/v]d={+>9"d+ހc46r,u$: /733>x}x:wdz۶>.Lpb}Ӆ` ~H'!gxI 1zwנ4`6`+ͦLd}cIfL9j r#  έxŞDh}Zkpj-0q#<^ ȓ|->r9<ʵ9Q3zp{9^☕掳tO[jɞ^Ɏ67^~mJkM&ųm"m~iLL֩vugQYI呸 ]λ# 6."mƘ66>8Qk'Ʊ[."^HGԬ3`2 <6嗀[[=S-:qvyimt^HI}t ?/DLЕv7Zl,6&4?fSXk 3qN*ަ;nzЍSÛ Sy-'t|1F 82Y19!qt/=ROcU))8,ۓMǡ۹3:\ ( =ѫ>Py-袡t>{toFtѭ2ٓZzT}J1 mGE_Gx`0>7˷1Q{fy}bf/ao 􈝏~h^ݼ^7/FjOs4ԝ? kdj?cl?׭v :̞xadw3޲/[2Nf6Waj_gkF z,C}(:6w{O{5VcO9[f+==GϤPĤIbbB+siw:qr ^fduܓjf, 7t7>܁;'7\OOcP >:]u?00͈~)&d23m?H=o~3Zi QS1<_getd͘u6;mF{ly,1%B&ҞX {٧} AUa24O;d*!feYpT=>UG:_w*@Uأ~o;f*1fY ̾ . P6b~qUa3fU'1?w*@Uؓ̾kNY {ٟ3spV3o;m*if P Өq:Ua3\f]puVֱًM PvK\UM욙m7*@Uة1; \U-fjpTnsZ ʮ6pV¶- PvA - WJ,3(K- PvA]nU+ JpT]%gPf; PvA]nUk zpTnrizI3Mjmp9*KJ39/3v:DW ^؈N59nU8;j"sª/ v:DU ^ؓt)T~tiT3V%xaϰө&2iD)&2uV%xaթ&2JNbV4YmbVL* ;Yj"bUYj"3۪/lfuLU ^VfuLU ^vfu թ&2J.bV,* Yj"ª/ fu*թ&2J®fVȬ* Yj"Ѫ/Ff7)W98 _%v:`HExaөC* N5$R^ؕt) vөC* N5$R^t) vөC* N /l;j H0"TS@!N /.v:`HExawөC* N5$R^ؽt) gSM T;j H0"TS@!=N /av:`HExaөC* {N5$R^ct) ө3/lN /qv:`HExaOөC* {N5$R^St) өC* {N5$R^3t) ¦Pj H0"uTS@!ᅝĬN5$R^&fu) NeV /l :`HExag3SM TYj H0"TS@!]N5$R^ETS@!]ʬN5$R^TS@!]ŬN5$R^TS@!]ˬN5$R^؍nRr 9ՄUSMCyN5! )/v:ՄH0t!|xaװө&C]N ɇN59$/l7;jrH0$^v:`H>TC!dSM N59$/nv:`H>{TC!eSM N59$/v:`H>TC!bSM {N59$/v:`H>GTC!cSM N ɇ6bSM {N59$/ v:`H>'TC!žbSM N ɇ4;jrH0$^3t!|xaT+K59$/l:`H>թ&CmbV ɇv*:`H>-TC!fV ɇYjrH0$^vfu!|xa0SM YjrH0$^إTC!®`V ɇv:`H>թ&C]ˬN59$/Ff7)78՜;߁u~'fO,Zsܥ-[Urm &5M3n\OZA]JkJiMb:K?zU-z Z7׾ȵ/r%5Ikεvmrd,6OoGp23ӧVW{uyfykI{oїqv}]r$j#`U{52/QaLݥ>? f?W? 8^q㺝u#Fttt_~g:&fGٞeǺ:cIgc>lK:UK޼YoG1cYcτ]f8l&5x*x&KgX N?p:V7i_cyOï*sCsv}w8*sCs]ΗL/i,274g| qKTenh{voi,_274g_+ÿǫsU? qp)A@Prd<ߝKnH]g~;ǘF?eUs Kя%MDz[nXt]y,s{ƖF?4WKng30Lq+й[nX *!$.XnF>psr{p7rmc ˍU-+f30̩274g5ǖF?U,gs30T <20\+_;pvv:wp&RgѰ.6ߦ͏nm=[Gz7o нyDpeӀ%eU=kY{Ｎሟv]?!yEO?]\6y|Q:'oML^LL^?lgr}B"[r Ʋ/6CmVy{vbڱ@޴tZ;koӵOٶxgSov?tGퟣ04Y]葍Xj2`.Yq[?LC/_W۶n;{ƩIϝUiٝYw*^F}ٖNYa.<>SQW*j E5&Kvէ1w.{p4WXLW={KA tS NrcOnqON{aI:S_י`_ݛ/^<ųi_6O}{Ous+ّ>]YM+kQ<хS:vw/uڅG/pc}~s r$ z  ymj0aUg+-I  20VJ2pF [/=0BEG SN&P ?T + CUOh+'0Q `h   $Presentacin de PowerPointManuel Iglesias RodaloiManuel Iglesias Rodaloi832Microsoft PowerPointoi@o<)$@ i<6@0G2^GPg  R('& &&#TNPPP2OMi & TNPP &&TNPP     'A x(xKʦ """)))UUUMMMBBB999|PP3f3333f333ff3fffff3f3f̙f3333f3333333333f3333333f3f33ff3f3f3f3333f3333333f3̙33333f333ff3ffffff3f33f3ff3f3f3ffff3fffffffff3fffffff3f̙ffff3ff333f3ff33fff33f3ff̙3f3f3333f333ff3fffff̙̙3̙f̙̙̙3f̙3f3f3333f333ff3fffff3f3f̙3ffffffffff!___wwwmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm½GGGGGGGGGGGGGGGGGGGG޽½½ý޽ý޽ýýýý޽ýýý޽޽޽޽ýýýýý޽޽޽ýýýý޽ý޽ý޽ý޽ýýýý޽޽޽ýý޽ýý޽ýýý޽ý޽ýý޽ýý޽޽޽ý޽ý޽޽޽mmmýýýýmmmmmmmmmmmmmmmmmmmmmmmmmmmmýmmmmmmmmmmmmmmmmmmmm޽mmmmmmmmm޽mmmmmmmmmmmmmmm޽mýmmmm޽mmmmmmm޽mmmmmmmmmmmmmmmmmmm޽mýmýmýmýýmýmm޽mmmmmmmmmmmmmmmmmmmmmmým޽mm޽m޽mmmmmmmmmmmmmmmmmmmmmmm޽mmmmmýmmmmmmmmmmýmmmmýmmmýý޽ý޽ýýmmmýý޽mmýýýýmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmýmmmmmmmm޽mmmmmmmmmmmmmmmmmmmmmmmýmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmýmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmýmmmmmmmmmmmmmýmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm޽ýýmý޽mýmmmmmmmmm޽mm޽ýmmmmmmý޽ý޽ýý޽ýýý޽޽ý޽޽ýýýý޽ý޽޽޽޽ýýýý޽޽ýý޽޽ýý޽ýýýý޽ý޽޽ýýýýýý޽ýýýýý޽ýý޽ýý޽޽޽ýýýýýýýý޽ýý޽ýý޽ý޽ýý޽ýýýýýý޽ý޽--&TNPP &՜.+,D՜.+,P    Presentacin en pantallah Medigrafin@   Times New RomanarialLucida Sans UnicodeTahomaDiseo predeterminado Grfico de Microsoft Graph 20003Es el etoricoxib un inhibidor de la COX-2 seguro?Antecedentes (1)Antecedentes (2) Objetivos Diseo (1) Diseo (2) Diseo (3)Resultados (1)Resultados (2)Resultados (3) ConclusionesComentario (1)Comentario (2) Fuentes usadasPlantilla de diseoServidores OLE incrustadosTtulos de diapositiva t 8@ _PID_HLINKSA,Hhttp://www.apaldia.com/;http://www.apaldia.com/resumenes/resumen.php?idresumen=151;http://www.apaldia.com/resumenes/resumen.php?idresumen=303/http://www.annals.org/cgi/content/full/145/1/1;http://www.apaldia.com/resumenes/resumen.php?idresumen=307;http://www.apaldia.com/resumenes/resumen.php?idresumen=307;http://www.apaldia.com/resumenes/resumen.php?idresumen=420;http://www.apaldia.com/resumenes/resumen.php?idresumen=430;http://www.apaldia.com/resumenes/resumen.php?idresumen=430Ohttp://www.thelancet.com/journals/lancet/article/PIIS0140673607602347/abstractOhttp://www.thelancet.com/journals/lancet/article/PIIS0140673607602347/fulltextOhttp://download.thelancet.com/pdfs/journals/0140-6736/PIIS0140673607602347.pdf-_DManuel Iglesias RodalManuel Iglesias Rodal  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$&'()*+,./012349Root EntrydO)PicturesCurrent User-SummaryInformation(RPowerPoint Document(XDDocumentSummaryInformation8%